Home Chemistry Heterocyclic Building Blocks Benzoxazoles 2-Phenylbenzo[D]Oxazole
Electrophilic Aromatic Substitution: The phenyl ring in 2-phenylbenzo[d]oxazole can undergo electrophilic aromatic substitution reactions. For example, it can react with electrophilic reagents like strong acids or acylating agents to introduce substituents onto the phenyl ring.
Nucleophilic Aromatic Substitution: If there are suitable electrophilic sites on the oxazole ring, nucleophilic aromatic substitution reactions can occur. Nucleophiles can displace certain substituents on the oxazole ring.
Reduction: 2-Phenylbenzo[d]oxazole may undergo reduction reactions, typically with reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4), to convert functional groups such as carbonyl groups into corresponding alcohols or other reduced forms.
Halogenation: The phenyl ring can be halogenated by treating 2-phenylbenzo[d]oxazole with halogenating agents like chlorine or bromine, resulting in the introduction of halogen substituents onto the phenyl ring.
Oxidation: Oxidation reactions can be used to convert functional groups within the compound. For example, the oxidation of a benzylic position can lead to the formation of a ketone or a carboxylic acid.
Esterification: The oxazole ring may undergo esterification reactions when treated with appropriate acylating agents, leading to the formation of esters.
Cross-Coupling Reactions: 2-Phenylbenzo[d]oxazole can be used in cross-coupling reactions, like Suzuki or Heck reactions, to create more complex molecules by connecting it with other suitable reagents.
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